Local lung hypoxia determines epithelial fate decisions during alveolar regeneration

After influenza infection, lineage-negative epithelial progenitors (LNEPs) exhibit a binary response to reconstitute epithelial barriers: activating a Notch-dependent ΔNp63/cytokeratin 5 (Krt5) remodelling program or differentiating into alveolar type II cells (AEC2s). Here we show that local lung h...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Cell Biol
Prif Awduron: Xi, Ying, Kim, Thomas, Brumwell, Alexis N., Driver, Ian H., Wei, Ying, Tan, Victor, Jackson, Julia R., Xu, Jianming, Lee, Dong-Kee, Gotts, Jeffrey E., Matthay, Michael A., Shannon, John M., Chapman, Harold A., Vaughan, Andrew E.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5600325/
https://ncbi.nlm.nih.gov/pubmed/28737769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3580
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