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Local lung hypoxia determines epithelial fate decisions during alveolar regeneration
After influenza infection, lineage-negative epithelial progenitors (LNEPs) exhibit a binary response to reconstitute epithelial barriers: activating a Notch-dependent ΔNp63/cytokeratin 5 (Krt5) remodelling program or differentiating into alveolar type II cells (AEC2s). Here we show that local lung h...
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| Izdano u: | Nat Cell Biol |
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| Glavni autori: | , , , , , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group UK
2017
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5600325/ https://ncbi.nlm.nih.gov/pubmed/28737769 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3580 |
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