Effects of the NEDD8-Activating Enzyme Inhibitor MLN4924 on Lytic Reactivation of Kaposi's Sarcoma-Associated Herpesvirus

The switch of Kaposi's sarcoma-associated herpesvirus (KSHV) from latency to lytic replication is a key event for viral dissemination and pathogenesis. MLN4924, a novel neddylation inhibitor, reportedly causes the onset of KSHV reactivation but impairs later phases of the viral lytic program in...

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Vydáno v:J Virol
Hlavní autoři: Chang, Pey-Jium, Chen, Lee-Wen, Chen, Li-Yu, Hung, Chien-Hui, Shih, Ying-Ju, Wang, Shie-Shan
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2017
Témata:
Genome Replication and Regulation of Viral Gene Expression
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5599746/
https://ncbi.nlm.nih.gov/pubmed/28701396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00505-17
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