New molecular insights into the tyrosyl-tRNA synthase inhibitors: CoMFA, CoMSIA analyses and molecular docking studies

Drug resistance caused by excessive and indiscriminate antibiotic usage has become a serious public health problem. The need of finding new antibacterial drugs is more urgent than ever before. Tyrosyl-tRNA synthase was proved to be a potent target in combating drug-resistant bacteria. In silico meth...

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Udgivet i:Sci Rep
Main Authors: Li, Shengrong, Fan, Jilin, Peng, Chengkang, Chang, Yiqun, Guo, Lianxia, Hou, Jinsong, Huang, Miaoqi, Wu, Biyuan, Zheng, Junxia, Lin, Longxin, Xiao, Gaokeng, Chen, Weimin, Liao, Guochao, Guo, Jialiang, Sun, Pinghua
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5599502/
https://ncbi.nlm.nih.gov/pubmed/28912450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-10618-1
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