A novel aromatic mutagen, 5-amino-6-hydroxy-8H-benzo[6,7]azepino[5,4,3-de]quinolin-7-one (ABAQ), induces colonic preneoplastic lesions in mice

The benzoazepinoqunolinone derivative, 5-amino-6-hydroxy-8H-benzo[6,7]azepino[5,4,3-de]quinolin-7-one (ABAQ), which is produced in a mixture of glucose and tryptophan incubated at 37 °C under physiological conditions in the presence or absence of hydroxyl radicals caused by the Fenton reaction, is a...

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Publicado en:Toxicol Rep
Main Authors: Kochi, Takahiro, Shimizu, Masahito, Totsuka, Yukari, Shirakami, Yohei, Nakanishi, Takayuki, Watanabe, Tetsushi, Tanaka, Takuji, Nakagama, Hitoshi, Wakabayashi, Keiji, Moriwaki, Hisataka
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5598209/
https://ncbi.nlm.nih.gov/pubmed/28962227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.toxrep.2014.04.006
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