Evolving DNA methylation and gene expression markers of B-cell chronic lymphocytic leukemia are present in pre-diagnostic blood samples more than 10 years prior to diagnosis

BACKGROUND: B-cell chronic lymphocytic leukemia (CLL) is a common type of adult leukemia. It often follows an indolent course and is preceded by monoclonal B-cell lymphocytosis, an asymptomatic condition, however it is not known what causes subjects with this condition to progress to CLL. Hence the...

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Udgivet i:BMC Genomics
Main Authors: Georgiadis, Panagiotis, Liampa, Irene, Hebels, Dennie G., Krauskopf, Julian, Chatziioannou, Aristotelis, Valavanis, Ioannis, de Kok, Theo M.C.M., Kleinjans, Jos C.S., Bergdahl, Ingvar A., Melin, Beatrice, Spaeth, Florentin, Palli, Domenico, Vermeulen, R.C.H., Vlaanderen, J., Chadeau-Hyam, Marc, Vineis, Paolo, Kyrtopoulos, Soterios A.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5598006/
https://ncbi.nlm.nih.gov/pubmed/28903739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12864-017-4117-4
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