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Identification of sites of 2′-O-methylation vulnerability in human ribosomal RNAs by systematic mapping
Ribosomal RNA modifications are important in optimizing ribosome function. Sugar 2′-O-methylation performed by fibrillarin-associated box C/D antisense guide snoRNAs impacts all steps of translation, playing a role in disease etiology (cancer). As it renders adjacent phosphodiester bonds resistant t...
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| Udgivet i: | Sci Rep |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group UK
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5597630/ https://ncbi.nlm.nih.gov/pubmed/28904332 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-09734-9 |
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