Polycystin-1 inhibits eIF2α phosphorylation and cell apoptosis through a PKR-eIF2α pathway

Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations in PKD1 or PKD2 which encodes polycystin-1 (PC1) and polycystin-2, respectively. PC1 was previously shown to slow cell proliferation and inhibit apoptosis but the underlying mechanisms remain elusive or controversial. Here w...

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Publicado en:Sci Rep
Main Authors: Tang, Yan, Wang, Zuocheng, Yang, JungWoo, Zheng, Wang, Chen, Di, Wu, Guanqing, Sandford, Richard, Tang, Jingfeng, Chen, Xing-Zhen
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5597606/
https://ncbi.nlm.nih.gov/pubmed/28904368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-11526-0
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