An Amish founder mutation disrupts a PI(3)P-WHAMM-Arp2/3 complex–driven autophagosomal remodeling pathway

Actin nucleation factors function to organize, shape, and move membrane-bound organelles, yet they remain poorly defined in relation to disease. Galloway-Mowat syndrome (GMS) is an inherited disorder characterized by microcephaly and nephrosis resulting from mutations in the WDR73 gene. This core cl...

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Veröffentlicht in:Mol Biol Cell
Hauptverfasser: Mathiowetz, Alyssa J., Baple, Emma, Russo, Ashley J., Coulter, Alyssa M., Carrano, Eric, Brown, Judith D., Jinks, Robert N., Crosby, Andrew H., Campellone, Kenneth G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Cell Biology 2017
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5597322/
https://ncbi.nlm.nih.gov/pubmed/28720660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E17-01-0022
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