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Multiscale biphasic modelling of peritumoural collagen microstructure: The effect of tumour growth on permeability and fluid flow

We present an in-silico model of avascular poroelastic tumour growth coupled with a multiscale biphasic description of the tumour–host environment. The model is specified to in-vitro data, facilitating biophysically realistic simulations of tumour spheroid growth into a dense collagen hydrogel. We u...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Wijeratne, Peter A., Hipwell, John H., Hawkes, David J., Stylianopoulos, Triantafyllos, Vavourakis, Vasileios
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5597211/
https://ncbi.nlm.nih.gov/pubmed/28902902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0184511
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