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In-silico dynamic analysis of cytotoxic drug administration to solid tumours: Effect of binding affinity and vessel permeability

The delivery of blood-borne therapeutic agents to solid tumours depends on a broad range of biophysical factors. We present a novel multiscale, multiphysics, in-silico modelling framework that encompasses dynamic tumour growth, angiogenesis and drug delivery, and use this model to simulate the intra...

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Detalhes bibliográficos
Publicado no:PLoS Comput Biol
Main Authors: Vavourakis, Vasileios, Stylianopoulos, Triantafyllos, Wijeratne, Peter A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6193741/
https://ncbi.nlm.nih.gov/pubmed/30296260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1006460
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