Copy number variation analysis in cytochromes and glutathione S-transferases may predict efficacy of tyrosine kinase inhibitors in chronic myeloid leukemia

Chronic myeloid leukemia (CML) is a myeloproliferative disease characterized by the presence of BCR/ABL fusion gene in leukemic cells, which promotes uncontrolled cell proliferation. Up to 20% of CML patients show primary resistance or non-optimal response to tyrosine kinase inhibitor (TKI) therapy....

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Pubblicato in:PLoS One
Autori principali: Lavrov, Alexander V., Ustaeva, Oksana A., Adilgereeva, Elmira P., Smirnikhina, Svetlana A., Chelysheva, Ekaterina Y., Shukhov, Oleg A., Shatokhin, Yuriy V., Mordanov, Sergey V., Turkina, Anna G., Kutsev, Sergey I.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2017
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5597128/
https://ncbi.nlm.nih.gov/pubmed/28902850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0182901
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