Dual role of DR5 in death and survival signaling leads to TRAIL resistance in cancer cells

Besides its tumor-selective apoptotic activity, tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) promotes pro-survival, proliferative or migratory signaling (NF-κB, PI3K/Akt, MAPK and JNK; referred to as 'non-apoptotic' cascades). Indeed, apoptosis and non-apoptotic signalin...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cell Death Dis
Egile Nagusiak: Shlyakhtina, Yelyzaveta, Pavet, Valeria, Gronemeyer, Hinrich
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2017
Gaiak:
Original Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5596601/
https://ncbi.nlm.nih.gov/pubmed/29048428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.423
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