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Tumor suppressor IRF-1 mediates retinoid and interferon anticancer signaling to death ligand TRAIL

Retinoids and interferons are signaling molecules with pronounced anticancer activity. We show that in both acute promyelocytic leukemia and breast cancer cells the retinoic acid (RA) and interferon signaling pathways converge on the promoter of the tumoricidal death ligand TRAIL. Promoter mapping,...

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Detalhes bibliográficos
Main Authors: Clarke, Nicole, Jimenez-Lara, Ana M, Voltz, Emilie, Gronemeyer, Hinrich
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC514919/
https://ncbi.nlm.nih.gov/pubmed/15241475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600302
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