A phase I open-label dose-escalation study of the anti-HER3 monoclonal antibody LJM716 in patients with advanced squamous cell carcinoma of the esophagus or head and neck and HER2-overexpressing breast or gastric cancer

BACKGROUND: Human epidermal growth factor receptor 3 (HER3) is important in maintaining epidermal growth factor receptor-driven cancers and mediating resistance to targeted therapy. A phase I study of anti-HER3 monoclonal antibody LJM716 was conducted with the primary objective to identify the maxim...

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Detalhes bibliográficos
Publicado no:BMC Cancer
Main Authors: Reynolds, Kerry Lynn, Bedard, Philippe L., Lee, Se-Hoon, Lin, Chia-Chi, Tabernero, Josep, Alsina, Maria, Cohen, Ezra, Baselga, José, Blumenschein, George, Graham, Donna M., Garrido-Laguna, Ignacio, Juric, Dejan, Sharma, Sunil, Salgia, Ravi, Seroutou, Abdelkader, Tian, Xianbin, Fernandez, Rose, Morozov, Alex, Sheng, Qing, Ramkumar, Thiruvamoor, Zubel, Angela, Bang, Yung-Jue
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5596462/
https://ncbi.nlm.nih.gov/pubmed/28899363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-017-3641-6
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