PD-L1 and IAPs co-operate to protect tumors from cytotoxic lymphocyte-derived TNF

Smac-mimetics are emerging as promising anti-cancer agents and are being evaluated in clinical trials for a variety of malignancies. Smac-mimetics can induce TNF production from a subset of tumor cells and simultaneously sensitize them to TNF-induced apoptosis. However, TNF derived from other cellul...

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Detalhes bibliográficos
Publicado no:Cell Death Differ
Main Authors: Kearney, Conor J, Lalaoui, Najoua, Freeman, Andrew J, Ramsbottom, Kelly M, Silke, John, Oliaro, Jane
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5596429/
https://ncbi.nlm.nih.gov/pubmed/28665401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2017.94
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