Binding of NAD(+)-Glycohydrolase to Streptolysin O Stabilizes Both Toxins and Promotes Virulence of Group A Streptococcus

The globally dominant, invasive M1T1 strain of group A Streptococcus (GAS) harbors polymorphisms in the promoter region of an operon that contains the genes encoding streptolysin O (SLO) and NAD(+)-glycohydrolase (NADase), resulting in high-level expression of these toxins. While both toxins have be...

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Udgivet i:mBio
Main Authors: Velarde, Jorge J., O’Seaghdha, Maghnus, Baddal, Buket, Bastiat-Sempe, Benedicte, Wessels, Michael R.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5596348/
https://ncbi.nlm.nih.gov/pubmed/28900022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01382-17
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