Activity-Related Conformational Changes in d,d-Carboxypeptidases Revealed by In Vivo Periplasmic Förster Resonance Energy Transfer Assay in Escherichia coli

One of the mechanisms of β-lactam antibiotic resistance requires the activity of d,d-carboxypeptidases (d,d-CPases) involved in peptidoglycan (PG) synthesis, making them putative targets for new antibiotic development. The activity of PG-synthesizing enzymes is often correlated with their associatio...

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Udgivet i:mBio
Main Authors: Meiresonne, Nils Y., van der Ploeg, René, Hink, Mark A., den Blaauwen, Tanneke
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5596342/
https://ncbi.nlm.nih.gov/pubmed/28900026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01089-17
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