The ocular toxicity and pharmacokinetics of simvastatin following intravitreal injection in mice

AIM: To investigate the retinal toxicity and pharmacokinetics of simvastatin intravitreally injected into mice. METHODS: Forty-eight 6-8-week-old C57BL/6J mice were used in this study. Simvastatin was intravitreally injected into the right eye of each mouse; the left eye was injected with vehicle an...

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Bibliographic Details
Published in:Int J Ophthalmol
Main Authors: Tse, Dennis Y., Kim, Seong Jae, Chung, Inyoung, He, Feng, Wensel, Theodore G., Wu, Samuel M.
Format: Artigo
Language:Inglês
Published: International Journal of Ophthalmology Press 2017
Subjects:
Basic Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5596219/
https://ncbi.nlm.nih.gov/pubmed/28944193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18240/ijo.2017.09.05
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