Sorafenib suppresses extrahepatic metastasis de novo in hepatocellular carcinoma through inhibition of mesenchymal cancer stem cells characterized by the expression of CD90

Cancer stem cells (CSCs) are a pivotal target for eradicating hepatocellular carcinoma (HCC). We previously reported that distinctive CSCs regulating tumorigenicity (EpCAM(+) CSCs) and metastasis (CD90(+) CSCs) have different epithelial/mesenchymal gene expression signatures. Here, we examined the i...

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Published in:Sci Rep
Main Authors: Yoshida, Mariko, Yamashita, Taro, Okada, Hikari, Oishi, Naoki, Nio, Kouki, Hayashi, Takehiro, Nomura, Yoshimoto, Hayashi, Tomoyuki, Asahina, Yoshiro, Ohwada, Mika, Sunagozaka, Hajime, Takatori, Hajime, Colombo, Federico, Porretti, Laura, Honda, Masao, Kaneko, Shuichi
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5596021/
https://ncbi.nlm.nih.gov/pubmed/28900199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-11848-z
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