A genome-wide association study identifies a novel susceptibility locus for the immunogenicity of polyethylene glycol

Conjugation of polyethylene glycol (PEG) to therapeutic molecules can improve bioavailability and therapeutic efficacy. However, some healthy individuals have pre-existing anti-PEG antibodies and certain patients develop anti-PEG antibody during treatment with PEGylated medicines, suggesting that ge...

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Publicado no:Nat Commun
Main Authors: Chang, Chia-Jung, Chen, Chien-Hsiun, Chen, Bing-Mae, Su, Yu-Cheng, Chen, Ying-Ting, Hershfield, Michael S., Lee, Ming-Ta Michael, Cheng, Tian-Lu, Chen, Yuan-Tsong, Roffler, Steve R., Wu, Jer-Yuarn
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5595925/
https://ncbi.nlm.nih.gov/pubmed/28900105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00622-4
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