Protective major histocompatibility complex allele prevents type 1 diabetes by shaping the intestinal microbiota early in ontogeny

Certain MHC-II or HLA-D alleles dominantly protect from particular autoimmune diseases. For example, expression of the MHC-II Eα:Eβ complex potently protects nonobese diabetic (NOD) mice, which normally lack this isotype, from spontaneous development of type 1 diabetes. However, the underlying mecha...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Silverman, Michael, Kua, Lindsay, Tanca, Alessandro, Pala, Mauro, Palomba, Antonio, Tanes, Ceylan, Bittinger, Kyle, Uzzau, Sergio, Benoist, Christophe, Mathis, Diane
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2017
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5594701/
https://ncbi.nlm.nih.gov/pubmed/28831005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1712280114
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