Metal-mediated diradical tuning for DNA replication arrest via template strand scission

A series of M(PyED)·X (X = 2Cl(−), SO(4)(2−)) pyridine–metalloenediyne complexes [M = Cu(II), Fe(II), or Zn(II)] and their independently synthesized, cyclized analogs have been prepared to investigate their potential as radical-generating DNA-damaging agents. All complexes possess a 1:1 metal-to-lig...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Porter, Meghan R., Lindahl, Sarah E., Lietzke, Anne, Metzger, Erin M., Wang, Quan, Henck, Erik, Chen, Chun-Hsing, Niu, Hengyao, Zaleski, Jeffrey M.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2017
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5594643/
https://ncbi.nlm.nih.gov/pubmed/28760964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1621349114
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