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Evasion of adaptive immunity by HIV through the action of host APOBEC3G/F enzymes
APOBEC3G (A3G) and APOBEC3F (A3F) are DNA-mutating enzymes expressed in T cells, dendritic cells and macrophages. A3G/F have been considered innate immune host factors, based on reports that they lethally mutate the HIV genome in vitro. In vivo, A3G/F effectiveness is limited by viral proteins, entr...
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| Veröffentlicht in: | AIDS Res Ther |
|---|---|
| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
BioMed Central
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5594601/ https://ncbi.nlm.nih.gov/pubmed/28893290 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12981-017-0173-8 |
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