5-methylcytosine promotes mRNA export — NSUN2 as the methyltransferase and ALYREF as an m(5)C reader

5-methylcytosine (m(5)C) is a post-transcriptional RNA modification identified in both stable and highly abundant tRNAs and rRNAs, and in mRNAs. However, its regulatory role in mRNA metabolism is still largely unknown. Here, we reveal that m(5)C modification is enriched in CG-rich regions and in regi...

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Gepubliceerd in:Cell Res
Hoofdauteurs: Yang, Xin, Yang, Ying, Sun, Bao-Fa, Chen, Yu-Sheng, Xu, Jia-Wei, Lai, Wei-Yi, Li, Ang, Wang, Xing, Bhattarai, Devi Prasad, Xiao, Wen, Sun, Hui-Ying, Zhu, Qin, Ma, Hai-Li, Adhikari, Samir, Sun, Min, Hao, Ya-Juan, Zhang, Bing, Huang, Chun-Min, Huang, Niu, Jiang, Gui-Bin, Zhao, Yong-Liang, Wang, Hai-Lin, Sun, Ying-Pu, Yang, Yun-Gui
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2017
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Original Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5594206/
https://ncbi.nlm.nih.gov/pubmed/28418038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2017.55
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