Cortisol overproduction results from DNA methylation of CYP11B1 in hypercortisolemia

Adrenocortical hormone excess, due to primary aldosteronism (PA) or hypercortisolemia, causes hypertension and cardiovascular complications. In PA, hypomethylation of aldosterone synthase (CYP11B2) is associated with aldosterone overproduction. However, in hypercortisolemia, the role of DNA methylat...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Kometani, Mitsuhiro, Yoneda, Takashi, Demura, Masashi, Koide, Hiroshi, Nishimoto, Koshiro, Mukai, Kuniaki, Gomez-Sanchez, Celso E., Akagi, Tadayuki, Yokota, Takashi, Horike, Shin-ichi, Karashima, Shigehiro, Miyamori, Isamu, Yamagishi, Masakazu, Takeda, Yoshiyu
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5594008/
https://ncbi.nlm.nih.gov/pubmed/28894201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-11435-2
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