Generation of a new mouse model of glaucoma characterized by reduced expression of the AP-2β and AP-2δ proteins

We generated 6 transgenic lines with insertion of an expression plasmid for the R883/M xanthine dehydrogenase (XDH) mutant protein. Approximately 20% of the animals deriving from one of the transgenic lines show ocular abnormalities and an increase in intra-ocular pressure which are consistent with...

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Vydáno v:Sci Rep
Hlavní autoři: Barzago, Maria Monica, Kurosaki, Mami, Fratelli, Maddalena, Bolis, Marco, Giudice, Chiara, Nordio, Laura, Cerri, Elisa, Domenici, Luciano, Terao, Mineko, Garattini, Enrico
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5593953/
https://ncbi.nlm.nih.gov/pubmed/28894266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-11752-6
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