TREM2 promotes Aβ phagocytosis by upregulating C/EBPα-dependent CD36 expression in microglia

TREM2 plays a critical role in the alleviation of Alzheimer’s disease by promoting Aβ phagocytosis by microglia, but the detailed molecular mechanism underlying TREM2-induced direct phagocytic activity of Aβ remains to be revealed. We found that learning and memory functions were improved in aged TR...

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Publicat a:Sci Rep
Autors principals: Kim, Su-Man, Mun, Bo-Ram, Lee, Sun-Jun, Joh, Yechan, Lee, Hwa-Youn, Ji, Kon-Young, Choi, Ha-Rim, Lee, Eun-Hee, Kim, Eun-Mi, Jang, Ji-Hye, Song, Hyeong-Woo, Mook-Jung, Inhee, Choi, Won-Seok, Kang, Hyung-Sik
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2017
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5593901/
https://ncbi.nlm.nih.gov/pubmed/28894284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-11634-x
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