Hypoxia inducible factor HIF-1 promotes myeloid-derived suppressor cells accumulation through ENTPD2/CD39L1 in hepatocellular carcinoma

Myeloid-derived suppressor cells (MDSCs) possess immunosuppressive activities, which allow cancers to escape immune surveillance and become non-responsive to immune checkpoints blockade. Here we report hypoxia as a cause of MDSC accumulation. Using hepatocellular carcinoma (HCC) as a cancer model, w...

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Publicat a:Nat Commun
Autors principals: Chiu, David Kung-Chun, Tse, Aki Pui-Wah, Xu, Iris Ming-Jing, Di Cui, Jane, Lai, Robin Kit-Ho, Li, Lynna Lan, Koh, Hui-Yu, Tsang, Felice Ho-Ching, Wei, Larry Lai, Wong, Chun-Ming, Ng, Irene Oi-Lin, Wong, Carmen Chak-Lui
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5593860/
https://ncbi.nlm.nih.gov/pubmed/28894087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00530-7
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