The frequency of neoantigens per somatic mutation rather than overall mutational load or number of predicted neoantigens per se is a prognostic factor in ovarian clear cell carcinoma

Neoantigens derived from tumor-specific somatic mutations are excellent targets for anti-tumor immune responses. In ovarian clear cell carcinoma (OCCC), checkpoint blockade yields durable responses in a subset of patients. To approach the question of why only some patients respond, we first investig...

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Bibliographic Details
Published in:Oncoimmunology
Main Authors: Matsushita, Hirokazu, Hasegawa, Kosei, Oda, Katsutoshi, Yamamoto, Shogo, Nishijima, Akira, Imai, Yuichi, Asada, Kayo, Ikeda, Yuji, Karasaki, Takahiro, Fujiwara, Keiichi, Aburatani, Hiroyuki, Kakimi, Kazuhiro
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2017
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5593715/
https://ncbi.nlm.nih.gov/pubmed/28920005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2017.1338996
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