MiR-148a impairs Ras/ERK signaling in B lymphocytes by targeting SOS proteins

Although microRNAs have been recognized as central cellular regulators, there is an evident lack of knowledge about their targets. Here, we analyzed potential target genes for miR-148a functioning in Ras signaling in B cells, including SOS1 and SOS2. A dual-luciferase reporter assay showed significa...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Oncotarget
Prif Awduron: Alles, Julia, Ludwig, Nicole, Rheinheimer, Stefanie, Leidinger, Petra, Grässer, Friedrich A., Keller, Andreas, Meese, Eckart
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Impact Journals LLC 2017
Pynciau:
Research Paper
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5593572/
https://ncbi.nlm.nih.gov/pubmed/28915601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.17662
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