Vorinostat suppresses hypoxia signaling by modulating nuclear translocation of hypoxia inducible factor 1 alpha

Histone deacetylase inhibitors (HDACis) are a potent class of tumor-suppressive agents traditionally believed to exert their effects through loosening tightly-wound chromatin resulting in de-inhibition of various tumor suppressive genes. Recent literature however has shown altered intratumoral hypox...

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Vydáno v:Oncotarget
Hlavní autoři: Zhang, Chao, Yang, Chunzhang, Feldman, Michael J., Wang, Herui, Pang, Ying, Maggio, Dominic M., Zhu, Dongwang, Nesvick, Cody L., Dmitriev, Pauline, Bullova, Petra, Chittiboina, Prashant, Brady, Roscoe O., Pacak, Karel, Zhuang, Zhengping
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2017
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5593548/
https://ncbi.nlm.nih.gov/pubmed/28915577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.18125
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