Melatonin inhibits Sirt1-dependent NAMPT and NFAT5 signaling in chondrocytes to attenuate osteoarthritis

Osteoarthritis (OA) is a degenerative joint disease mainly characterized by cartilage degradation. Interleukin-1β (IL-1β) contributes to OA pathogenesis by enhancing oxidative stress and inflammation. Melatonin reportedly elicits potent protection against OA. However, the role of melatonin and under...

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Опубликовано в: :Oncotarget
Главные авторы: Guo, Jia Yi, Li, Feng, Wen, Yong Bing, Cui, Hong Xun, Guo, Ma Long, Zhang, Lin, Zhang, Yun Fei, Guo, Yan Jin, Guo, Yan Xing
Формат: Artigo
Язык:Inglês
Опубликовано: Impact Journals LLC 2017
Предметы:
Research Paper: Immunology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5593538/
https://ncbi.nlm.nih.gov/pubmed/28915567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.18356
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