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Inhibition of Transient Receptor Potential Melastatin 3 ion channels by G-protein βγ subunits
Transient receptor potential melastatin 3 (TRPM3) channels are activated by heat, and chemical ligands such as pregnenolone sulphate (PregS) and CIM0216. Here, we show that activation of receptors coupled to heterotrimeric Gi/o proteins inhibits TRPM3 channels. This inhibition was alleviated by co-e...
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| Publicado no: | eLife |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5593506/ https://ncbi.nlm.nih.gov/pubmed/28829742 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.26147 |
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