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Intra‐Target Microdosing – A Novel Drug Development Approach: Proof of Concept, Safety, and Feasibility Study in Humans

Intra‐Target Microdosing (ITM) is a novel drug development approach aimed at increasing the efficiency of first‐in‐human (FIH) testing of new molecular entities (NMEs). ITM combines intra‐target drug delivery and “microdosing,” the subpharmacological systemic exposure. We hypothesized that when the...

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Detalhes bibliográficos
Publicado no:Clin Transl Sci
Main Authors: Burt, T, MacLeod, D, Lee, K, Santoro, A, DeMasi, DK, Hawk, T, Feinglos, M, Rowland, M, Noveck, RJ
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5593161/
https://ncbi.nlm.nih.gov/pubmed/28689370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cts.12477
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