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Two Types of Etiological Mutation in the Limb-Specific Enhancer of Shh
An enhancer named MFCS1 regulates Sonic hedgehog (Shh) expression in the posterior mesenchyme of limb buds. Several mutations in MFCS1 induce ectopic Shh expression in the anterior limb bud, and these result in preaxial polydactyly (PPD). However, the molecular basis of ectopic Shh expression remain...
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| Publicado no: | G3 (Bethesda) |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Genetics Society of America
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5592926/ https://ncbi.nlm.nih.gov/pubmed/28710291 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/g3.117.044669 |
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