Altered Met receptor phosphorylation and LRP1-mediated uptake in cells lacking carbohydrate-dependent lysosomal targeting

Acid hydrolases utilize a carbohydrate-dependent mechanism for lysosomal targeting. These hydrolases acquire a mannose 6-phosphate tag by the action of the GlcNAc-1-phosphotransferase enzyme, allowing them to bind receptors and traffic to endosomes. Loss of GlcNAc-1-phosphotransferase results in hyd...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Aarnio-Peterson, Megan, Zhao, Peng, Yu, Seok-Ho, Christian, Courtney, Flanagan-Steet, Heather, Wells, Lance, Steet, Richard
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2017
Schlagworte:
Glycobiology and Extracellular Matrices
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5592684/
https://ncbi.nlm.nih.gov/pubmed/28724630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.790139
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