Increased MAPK1/3 Phosphorylation in Luminal Breast Cancer Related with PIK3CA Hotspot Mutations and Prognosis

INTRODUCTION: While mutations in PIK3CA are most frequently (45%) detected in luminal breast cancer, downstream PI3K/AKT/mTOR pathway activation is predominantly observed in the basal subtype. The aim was to identify proteins activated in PIK3CA mutated luminal breast cancer and the clinical relevan...

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Publicado en:Transl Oncol
Main Authors: Ramirez-Ardila, Diana, Timmermans, A. Mieke, Helmijr, Jean A., Martens, John W.M., Berns, Els M.J.J., Jansen, Maurice P.H.M.
Formato: Artigo
Idioma:Inglês
Publicado: Neoplasia Press 2017
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Original article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5591392/
https://ncbi.nlm.nih.gov/pubmed/28886403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2017.08.002
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