Metabolic stress-induced cardiomyopathy is caused by mitochondrial dysfunction due to attenuated Erk5 signaling

The prevalence of cardiomyopathy from metabolic stress has increased dramatically; however, its molecular mechanisms remain elusive. Here, we show that extracellular signal-regulated protein kinase 5 (Erk5) is lost in the hearts of obese/diabetic animal models and that cardiac-specific deletion of E...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Liu, Wei, Ruiz-Velasco, Andrea, Wang, Shoubao, Khan, Saba, Zi, Min, Jungmann, Andreas, Dolores Camacho-Muñoz, Maria, Guo, Jing, Du, Guanhua, Xie, Liping, Oceandy, Delvac, Nicolaou, Anna, Galli, Gina, Müller, Oliver J., Cartwright, Elizabeth J., Ji, Yong, Wang, Xin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5591279/
https://ncbi.nlm.nih.gov/pubmed/28887535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00664-8
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