Metabolic stress-induced cardiomyopathy is caused by mitochondrial dysfunction due to attenuated Erk5 signaling

The prevalence of cardiomyopathy from metabolic stress has increased dramatically; however, its molecular mechanisms remain elusive. Here, we show that extracellular signal-regulated protein kinase 5 (Erk5) is lost in the hearts of obese/diabetic animal models and that cardiac-specific deletion of E...

Full description

Saved in:
Bibliographic Details
Published in:Nat Commun
Main Authors: Liu, Wei, Ruiz-Velasco, Andrea, Wang, Shoubao, Khan, Saba, Zi, Min, Jungmann, Andreas, Dolores Camacho-Muñoz, Maria, Guo, Jing, Du, Guanhua, Xie, Liping, Oceandy, Delvac, Nicolaou, Anna, Galli, Gina, Müller, Oliver J., Cartwright, Elizabeth J., Ji, Yong, Wang, Xin
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5591279/
https://ncbi.nlm.nih.gov/pubmed/28887535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00664-8
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items