Host immune status-specific production of gliotoxin and bis-methyl-gliotoxin during invasive aspergillosis in mice

Delayed diagnosis in invasive aspergillosis (IA) contributes to its high mortality. Gliotoxin (GT) and bis-methyl-gliotoxin (bmGT) are secondary metabolites produced by Aspergillus during invasive, hyphal growth and may prove diagnostically useful. Because IA pathophysiology and GT’s role in virulen...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Sugui, Janyce A., Rose, Stacey R., Nardone, Glenn, Swamydas, Muthulekha, Lee, Chyi-Chia R., Kwon-Chung, Kyung J., Lionakis, Michail S.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5591180/
https://ncbi.nlm.nih.gov/pubmed/28887465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-10888-9
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