Modeling of TREX1-dependent autoimmune disease using human stem cells highlights L1 accumulation as a source of neuroinflammation

Three-prime repair exonuclease I (TREX1) is an anti-viral enzyme that cleaves nucleic acids in the cytosol, preventing accumulation and a subsequent type-I interferon-associated inflammatory response. Autoimmune diseases, including Aicardi-Goutières syndrome (AGS) and systemic lupus erythematosus, c...

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Udgivet i:Cell Stem Cell
Main Authors: Thomas, Charles A., Tejwani, Leon, Trujillo, Cleber A., Negraes, Priscilla D., Herai, Roberto H., Mesci, Pinar, Macia, Angela, Crow, Yanick J., Muotri, Alysson R.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5591075/
https://ncbi.nlm.nih.gov/pubmed/28803918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2017.07.009
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