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Trex1 prevents cell-intrinsic initiation of autoimmunity
Detection of nucleic acids and induction of type I interferons (IFNs) are principal elements of antiviral defense, but can cause autoimmunity if misregulated. Cytosolic DNA detection activates a potent, cell-intrinsic antiviral response through a poorly defined pathway. In a screen for proteins rele...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2626626/ https://ncbi.nlm.nih.gov/pubmed/18724932 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2008.06.032 |
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