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Domain-based prediction of the human isoform interactome provides insights into the functional impact of alternative splicing

Alternative splicing is known to remodel protein-protein interaction networks (“interactomes”), yet large-scale determination of isoform-specific interactions remains challenging. We present a domain-based method to predict the isoform interactome from the reference interactome. First, we construct...

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Bibliografische gegevens
Gepubliceerd in:PLoS Comput Biol
Hoofdauteurs: Ghadie, Mohamed Ali, Lambourne, Luke, Vidal, Marc, Xia, Yu
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2017
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5591010/
https://ncbi.nlm.nih.gov/pubmed/28846689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005717
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