Activation of endoplasmic reticulum stress response by enhanced polyamine catabolism is important in the mediation of cisplatin-induced acute kidney injury

Cisplatin-induced nephrotoxicity limits its use in many cancer patients. The expression of enzymes involved in polyamine catabolism, spermidine/spermine N(1)-acetyltransferase (SSAT) and spermine oxidase (SMOX) increase in the kidneys of mice treated with cisplatin. We hypothesized that enhanced pol...

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Udgivet i:PLoS One
Main Authors: Zahedi, Kamyar, Barone, Sharon, Destefano-Shields, Christina, Brooks, Marybeth, Murray-Stewart, Tracy, Dunworth, Matthew, Li, Weimin, Doherty, Joanne R., Hall, Mark A., Smith, Roger D., Cleveland, John L., Casero, Robert A., Soleimani, Manoocher
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5590979/
https://ncbi.nlm.nih.gov/pubmed/28886181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0184570
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