Incidence of pancreatic cancer is dramatically increased by a high fat, high calorie diet in KrasG12D mice

Epidemiologic data has linked obesity to a higher risk of pancreatic cancer, but the underlying mechanisms are poorly understood. To allow for detailed mechanistic studies in a relevant model mimicking diet-induced obesity and pancreatic cancer, a high-fat, high-calorie diet (HFCD) was given to P48(...

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Vydáno v:PLoS One
Hlavní autoři: Chang, Hui-Hua, Moro, Aune, Takakura, Kazuki, Su, Hsin-Yuan, Mo, Allen, Nakanishi, Masako, Waldron, Richard T., French, Samuel W., Dawson, David W., Hines, O. Joe, Li, Gang, Go, Vay Liang W., Sinnett-Smith, James, Pandol, Stephen J., Lugea, Aurelia, Gukovskaya, Anna S., Duff, Michael O., Rosenberg, Daniel W., Rozengurt, Enrique, Eibl, Guido
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2017
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5590955/
https://ncbi.nlm.nih.gov/pubmed/28886117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0184455
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