Acyl Carrier Protein Cyanylation Delivers a Ketoacyl Synthase-Carrier Protein Crosslink

Acyl carrier proteins (ACPs) are central hubs in polyketide and fatty acid biosynthetic pathways, but the fast motions of the ACP’s phosphopantetheine (Ppant) arm make its conformational dynamics difficult to capture using traditional spectroscopic approaches. Here we report that converting the term...

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Udgivet i:Biochemistry
Main Authors: Thiele, Grace A., Friedman, Connie P., Tsai, Kathleen J. S., Beld, Joris, Londergan, Casey H., Charkoudian, Louise K.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5590888/
https://ncbi.nlm.nih.gov/pubmed/28448715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.7b00219
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