Genetic variants in CYP2B6 and CYP2A6 explain interindividual variation in efavirenz plasma concentrations of HIV-infected children with diverse ethnic origin

BACKGROUND: Approximately 2.6 million children live with HIV globally, and efavirenz (EFV) is one of the most widely used antiretroviral agents for HIV treatment in children and adults. There are concerns about the appropriateness of current EFV dosing and it has been discussed whether EFV dosing sh...

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發表在:PLoS One
Main Authors: Soeria-Atmadja, Sandra, Österberg, Emma, Gustafsson, Lars L., Dahl, Marja-Liisa, Eriksen, Jaran, Rubin, Johanna, Navér, Lars
格式: Artigo
語言:Inglês
出版: Public Library of Science 2017
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Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5590735/
https://ncbi.nlm.nih.gov/pubmed/28886044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0181316
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