Molecular genetics of CYP2D6: Clinical relevance with focus on psychotropic drugs

Cytochrome P450 CYP2D6 is the most extensively characterized polymorphic drug-metabolizing enzyme. A deficiency of the CYP2D6 enzyme is inherited as an autosomal recessive trait; these subjects (7% of Caucasians, about 1% of Orientals) are classified as poor metabolizers. Among the rest (extensive m...

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Main Authors: Bertilsson, Leif, Dahl, Marja-Liisa, Dalén, Per, Al-Shurbaji, Ayman
Formato: Artigo
Idioma:Inglês
Publicado: Blackwell Science, Ltd 2002
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1874287/
https://ncbi.nlm.nih.gov/pubmed/11851634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.0306-5251.2001.01548.x
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