Development of Fluorescent Probes that Target Serotonin 5-HT(2B) Receptors

Some 5-HT(2B) fluorescent probes were obtained by tagging 1-(2,5-dimethoxy-4-iodophenyl)-propan-2-amine (DOI) with a subset of fluorescent amines. Some of the resulting fluorescent ligands showed excellent affinity and selectivity profiles at the 5-HT(2B) receptors (e.g. 12b), while retain the agoni...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Azuaje, Jhonny, López, Paula, Iglesias, Alba, de la Fuente, Rocío A., Pérez-Rubio, José M., García, Diego, Stępniewski, Tomasz Maciej, García-Mera, Xerardo, Brea, José M., Selent, Jana, Pérez, Dolores, Castro, Marián, Loza, María I., Sotelo, Eddy
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5589878/
https://ncbi.nlm.nih.gov/pubmed/28883627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-11370-2
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